Loxigen

Founder & Members

Ozgur Sahin, PhD

Dr. Sahin is an experienced cancer biologist with a strong background in cancer biology, functional genomics, bioinformatics, and drug discovery. He discovered the roles of many proteins and non-coding RNAs in the pathogenesis of drug resistant and metastatic cancers. Dr. Sahin is currently a Professor and Endowed Chair in the Department of Biochemistry & Molecular Biology at Medical University of South Carolina (MUSC), Charleston, SC. He is also the Program Director for Basic Science Translation and the Co-leader of the Breast Transdisciplinary Cancer Team (TcT) at NCI-designated MUCS Hollings Cancer Center. Previously, he served as Research Team Leader at German Cancer Research Center (DKFZ), Research Faculty in the Department of Molecular & Cellular Oncology at the University of Texas MD Anderson Cancer Center (MDACC), Assistant Professor in the Department of Molecular Biology & Genetics at Bilkent University and Associate Professor in the Department of Drug Discovery & Biomedical Sciences at the University of South Carolina. To date, Dr. Sahin published more than 80 peer-reviewed papers in the field of cancer research/drug discovery in high impact international journals and filed multiple patent applications. He is also co-founder and manager of OncoCube Therapeutics and a member of the scientific advisory board of A2A Pharmaceuticals.

Email: sahin@loxigen.com

Founder and President

Founder and President

Ozgur Sahin, PhD

Dr. Sahin is an experienced cancer biologist with a strong background in cancer biology, functional genomics, bioinformatics, and drug discovery. He discovered the roles of many proteins and non-coding RNAs in the pathogenesis of drug resistant and metastatic cancers. Dr. Sahin is currently a Professor and Endowed Chair in the Department of Biochemistry & Molecular Biology at Medical University of South Carolina (MUSC), Charleston, SC. He is also the Program Director for Basic Science Translation and the Co-leader of the Breast Transdisciplinary Cancer Team (TcT) at NCI-designated MUCS Hollings Cancer Center. Previously, he served as Research Team Leader at German Cancer Research Center (DKFZ), Research Faculty in the Department of Molecular & Cellular Oncology at the University of Texas MD Anderson Cancer Center (MDACC), Assistant Professor in the Department of Molecular Biology & Genetics at Bilkent University and Associate Professor in the Department of Drug Discovery & Biomedical Sciences at the University of South Carolina. To date, Dr. Sahin published more than 80 peer-reviewed papers in the field of cancer research/drug discovery in high impact international journals and filed multiple patent applications. He is also co-founder and manager of OncoCube Therapeutics and a member of the scientific advisory board of A2A Pharmaceuticals.

Email: sahin@loxigen.com

Bill Xingjun Wu, PhD

Dr. Wu is a researcher with more than 20 years of expertise in biomedical research and has authored over 50 publications (https://www.ncbi.nlm.nih.gov/myncbi/1dkHabagjb6Ad/bibliography/public/). He has a long-standing interest in developing novel therapeutic strategies against cancers. So, after acquiring his PhD at MUSC in 2004, he investigated the biochemical properties of sphingolipid enzymes and their roles and regulations of sphingolipids in inflammation and cancer. From 2012 to 2022, he served as a faculty member at MUSC and OSU. Together with his colleagues, he has identified GARP, a TGFβ regulator, as a potential target for cancer therapy. He has successfully developed antibodies and CAR-T against GARP for cancer therapy (NCT06964737). From 2022 to 2024, he worked at Biocytogen Boston Corporation as a senior scientist and project manager in the pharmacology team, where he completed pharmacology projects and provided technical consultation for CRO pharmacology services. Currently, he focuses on developing innovative LOX inhibitors for cancer therapy.

Email: manager@loxigen.com

Director of Research

Director of Research

Bill Xingjun Wu, PhD

Dr. Wu is a researcher with more than 20 years of expertise in biomedical research and has authored over 50 publications (https://www.ncbi.nlm.nih.gov/myncbi/1dkHabagjb6Ad/bibliography/public/). He has a long-standing interest in developing novel therapeutic strategies against cancers. So, after acquiring his PhD at MUSC in 2004, he investigated the biochemical properties of sphingolipid enzymes and their roles and regulations of sphingolipids in inflammation and cancer. From 2012 to 2022, he served as a faculty member at MUSC and OSU. Together with his colleagues, he has identified GARP, a TGFβ regulator, as a potential target for cancer therapy. He has successfully developed antibodies and CAR-T against GARP for cancer therapy (NCT06964737). From 2022 to 2024, he worked at Biocytogen Boston Corporation as a senior scientist and project manager in the pharmacology team, where he completed pharmacology projects and provided technical consultation for CRO pharmacology services. Currently, he focuses on developing innovative LOX inhibitors for cancer therapy.

Email: manager@loxigen.com